In a major medical breakthrough, a woman in Alabama lived for 130 days with a genetically modified pig kidney before her body started to reject it. The surgery was done on November 25 at NYU Langone Health in New York and set a record for the longest time anyone has survived with a gene-edited pig organ. On April 4, the organ was removed due to signs of rejection, and the patient has returned to dialysis. This was part of an experimental process called xenotransplantation, which means transplanting animal organs into humans. Scientists are exploring this to help with the shortage of human donor organs—over 100,000 people in the U.S. are still waiting for a transplant.

Doctors said the case gave valuable information for future trials. Dr. Robert Montgomery, the lead surgeon, said removing the organ was safer than giving stronger anti-rejection drugs. A mild infection and changes to medication may have caused the rejection. Even though problems occurred, the pig kidney worked well at first and gave the patient a break from dialysis. Experts say this pivotal case could catalyze research to improve compatibility, prevent rejection, and boost resilience in future animal-to-human transplants.