Unapproved peptide drugs have become a growing trend in the United States, where online influencers, fitness coaches, and well-known public figures continue to promote them for muscle growth, weight loss, and anti-aging purposes. The rise began when online shops started selling injectable vials priced from 300 to 600 dollars, and wellness clinics offered in-office injections with monthly membership fees costing thousands of dollars. The interest increased because peptides are naturally found in the body and support important biological functions, including blood sugar control. However, many of the products gaining attention have never been examined through large human studies. Specialists warned that this lack of strong evidence could result in allergic reactions, metabolic problems, or other harmful outcomes. Regulators also reported that most unapproved peptides sold online are considered illegal because injected substances meant to improve health must receive approval from the Food and Drug Administration. In addition, some peptides have already been banned in sports due to doping concerns, creating a contentious debate about their safety.

Experts stated that the situation has become more complex because many influencers encourage combining several peptides at the same time, a practice viewed as hazardous by medical researchers. Pharmaceutical authorities noted that most injectable peptides come from compounding pharmacies, which follow state rules and therefore operate with less federal oversight. The agency recently expanded a list of substances that should not be compounded due to safety risks, signaling increasing scrutiny. Analysts explained that strong commercial interest has led to escalating promotion, sometimes supported by ambiguous claims and unsubstantiated benefits. Health professionals noted that these developments may create significant challenges for individuals seeking safe and evidence-based treatments.